BENEFICIARY 06 - POLIMI

BRIEF DESCRIPTION OF THE ORGANIZATION   

The Department of Electronics and Information Technology is the largest department of Politecnico di Milano and counts 167 faculty members and 250 short-term researchers and Ph.D. students. It is organized in four distinct scientific areas: computer science, telecommunications, control systems and electronics. DEI is also a key node of many research networks in the fields of bio-engineering, physical science and all activities that need electronic expertise. The Electronic group of the Department is focusing its research activity in the science and technology of microelectronic and optoelectronic devices, circuits and systems and support new developments in diversified fields of interest for the present-day society, such as application of nanoelectronic and diagnostic technologies to genetics and biomedicine, to High Energy Physics or to the preservation of cultural heritage.

The Instrumentation & Measurement group of POLIMI has a wide experience in the field of high-sensitivity instrumentation for the nanoscience. In particular the POLIMI group has developed and patented a new low-noise wide-band current amplifier for nanoscale impedance microscopy, which has allowed to access for the first time local quantitative information on the intrinsic electric properties of materials at the nanoscale. Moreover, the group has realized single-chip measuring circuits for current measurements on electrical nanobiosensors. The expertise of the group is a guarantee for the implementation of state of art custom electronic instrumentation and for the access and characterization of the electrical signals generated by the olfactory receptors.


MAIN TASKS WITHIN THE PROJECT

In the Bond Project the group will design, fabricate and test a specially conceived integrated electronic circuitry for the detection of the signals from the nanoscaled electrochemical cell. The electronic system will comply with the peculiar situation of this bioexperiment: i) the presence of only single receptors, thus limiting the signal to very low levels and imposing very low noise front-end acquisition systems; ii) the presence of a physiological saline solution that produce ionic bias currents in addition to the signal currents, thus imposing large dynamic range amplifiers for the steady currents (that is low DC gain) but still large amplification for the signal without introducing additional noise; iii) the presence of conformational changes in the biomolecules as the effect of the odorant interaction, thus producing modifications of device impedance. To this aim, state of the art electronic solutions will be implemented by the group of POLIMI with the most innovative solutions to fulfil the highly demanding requirements of the BOND application.

PREVIOUS EXPERIENCE

The research team directed by Marco Sampietro coordinates many national and international research projects and it is a partner in three large-size European projects.

CONTACT

Marco SAMPIETRO
Professor of Electronics in the Faculty of Electrical Engineering and Information Technology at Politecnico di Milano

Politecnico di Milano  
Dipartimento di Elettronica e Informazione   
P.za L. da Vinci 32  
20133 Milano (ITALY)  
Tel. + 39 0223 996 188
Fax. + 39 02 2399 3574
Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Web: http://www.dei.polimi.it

KEY PEOPLE  

Marco Sampietro is Full Professor of Electronics at the Politecnico di Milano, Italy. He is responsible for the activities in the field of high-sensitivity instrumentation for the nanoscience (Instrumentation & Measurement group), aiming to investigate the electrical properties of organic semiconductor molecules and of biological materials. His group has developed instrumentation for electrical analysis of nanodevices and applied it to the study of single spin resonant phenomena through the investigation of single charge trapping & detrapping in MOSFETs under strong magnetic fields and at sub-kelvin temperatures. He is now investigating the electrical properties of biological materials with emphasis on the electrical response of mammal olfactory receptors upon interaction with specific odorants, aiming to explore high sensitive and selective bio-sensors. To address the single nanosome, the group has developed a special AFM (atomic force microscope) that performs impedance spectroscopy measurements with sub-attofarad resolution on nanometric areas. On-chip instrumentation is the goal of present activity, to better address the need of high performance and portability in the nano-bio science. He is co-author of more than 140 peer-reviewed international publications and holds 3 patents. He has been vice-dean of the Faculty and the coordinator of many national and international research projects and partner in three large-size European projects.

Giorgio Ferrari was born in Novara (Italy) in 1973. He received the Laurea degree and the Ph.D. degree from Politecnico di Milano in Electronics Engineering in 1999 and 2003, respectively. From 2002 to 2003 he had a fellowship at MDM Laboratory of Italian Institute for the Physics of Matter (Agrate Brianza, Italy) to develop circuits for the investigation of single spin resonant phenomena in silicon MOS devices operating at cryogenic temperature. In 2005, he joined the Department of Electronics Engineering of Politecnico di Milano as Assistant Professor. He has contributed to conceive and to build a Correlation Spectrum Analyzer for current and voltage noise measurements that reach a sensitivity more than two order of magnitude better than commercially available instruments. He is currently involved in the development of single-chip measuring circuits (Instrument-in-a-chip) for current, voltage, and impedance determination of nanosamples and biomolecules and developed electronic systems for electrochemical measurements on biological materials. He is co-author of 25 papers on international journals and has contributed with more than 20 papers to conferences. He is co-inventor of three patents.